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Author: Admin | 2025-04-28
1 or 2 minutes prior to administration, as instilling a cold suspension may cause dizziness. The usual dose is to instill 4 drops of ciprofloxacin/dexamethasone, which contain 0.42 mg ciprofloxacin and 0.14 mg dexamethasone, into the affected ear twice daily for 7 days.The patient should lie with the affected ear upward before instilling the drops and should stay in the same position for 60 seconds. They should repeat, if necessary, for the opposite ear.For acute otitis media, the patient or caregiver should press the tragus (the small projection in front of the ear canal) 5 times with a pumping motion to allow the drops to enter the middle ear. For acute otitis externa, patients should gently pull the outer ear lobe upward and backward to allow the drops to enter the ear canal.Ciprofloxacin/dexamethasone is for otic use (ears) only and should not be administered to the eyes or by injection. Counsel patients to avoid contamination of the bottle tip with material from the ear, fingers, or other sources. The patient should complete the full treatment regimen, even if symptoms improve before 7 days, and discard unused portions.Adverse Effects (AEs)1The most common AEs reported during clinical trials include ear discomfort, ear pain, and ear pruritus.Contraindications1Ciprofloxacin/dexamethasone is contraindicated in patients with a history of hypersensitivity to ciprofloxacin, other quinolones, or any excipients. The medication is also contraindicated in viral infections of the external canal, including herpes simplex infections and fungal otic infections.Warning and Precautions1Patients should discontinue use if any allergic reaction occurs with ciprofloxacin/dexamethasone. Possible symptoms include urticaria and facial swelling.Prolonged use may lead to overgrowth of non-susceptible bacteria and fungi. If the infection does not improve after 1 week, the health care provider should obtain cultures to guide further treatment, discontinue ciprofloxacin/dexamethasone use, and implement alternative therapy.If otorrhea persists after a full therapy course, or if 2 or more episodes of otorrhea occur within 6 months, providers should evaluate further to exclude an underlying condition, such as cholesteatoma, foreign body, or a tumor.Pregnancy and Lactation1No data are available on ciprofloxacin/dexamethasone use in pregnant women to evaluate for teratogenicity, miscarriage or adverse maternal, or fetal outcomes. This product is expected to be of minimal risk for maternal and fetal toxicity when administered to pregnant women, due to the minimal systemic absorption of ciprofloxacin and dexamethasone following topical otic administration.The effects of ciprofloxacin and dexamethasone following topical otic administration in terms of human
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